Fluid Structure Interactions in Ascending Thoracic Aortic Aneurysms

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Biaxial rupture properties of ascending thoracic aortic aneurysms.

UNLABELLED Although hundreds of samples obtained from ascending thoracic aortic aneurysms (ATAA) of patients undergoing elective surgical repair have already been characterized biomechanically, their rupture properties were always derived from uniaxial tensile tests. Due to their bulge shape, ATAAs are stretched biaxially in vivo. In order to understand the biaxial rupture of ATAAs, our group d...

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Thoracic Aortic Aneurysms

The true incidence and mortality rate of TAAs is not known. A population-based study reported an incidence of 5.9 new aneurysms per 100,000 person-years in a Midwestern community over a 30-year period with median ages of 65 years for men and 77 years for women. 51% of aneurysms were in the ascending aorta, 11% in the arch and 38% in the descending thoracic aorta. Prevalence may be at least 3-4 ...

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Ascending Aneurysms in Bicuspid Aortic Valve

The bicuspid aortic valve (BAV), the most common congenital cardiac malformation, is associated with ascending thoracic aneurysms and appears to reflect a common developmental defect. (Hahn et al., 1992; Roberts, 1970) The average time of patients with BAV undergoing surgery (of the aortic valve and/or because of complications associated with it) is a decade earlier than patients with a normall...

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Thoracic and abdominal aortic aneurysms.

Aneurysms of the aorta are at times evaluated and treated by physicians from a number of specialties. Indeed, whereas cardiac surgeons operate on the ascending aorta and arch and vascular surgeons manage abdominal aortic aneurysms, at present the responsibility often falls to cardiologists to oversee the medical care of patients with aortic disease of all types. However, although formally train...

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Differential expression of collagen type V and XI alpha-1 in human ascending thoracic aortic aneurysms.

BACKGROUND The molecular mechanisms leading to ascending thoracic aortic aneurysms (ATAAs) remain unknown. We hypothesized that alterations in expression levels of specific fibrillar collagens occur during the aneurysmal process. METHODS Surgical samples from ascending aortas from patients with degenerative ATAAs were subdivided by aneurysm diameter: small, 5 to 6 cm; medium, 6 to 7 cm; and l...

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ژورنال

عنوان ژورنال: Molecular & Cellular Biomechanics

سال: 2019

ISSN: 1556-5300

DOI: 10.32604/mcb.2019.05705